Botanical Cube Inc. is one of the most professional manufacturers and suppliers of dihydroberberine powder in China, featured by quality products and good price. Please rest assured to wholesale bulk discount dihydroberberine powder from our factory.
Dihydroberberine (DHB) is a reduced and more bioavailable derivative of berberine, designed to improve absorption efficiency in the human body. Compared with traditional berberine, DHB is converted into active berberine after absorption, helping to enhance its utilization performance in dietary supplement formulations.
Dihydroberberine Powder is manufactured for industrial-scale nutraceutical production where batch consistency and formulation stability directly impact final product performance.As a Dihydroberberine Powder supplier and OEM manufacturer, we do not operate as a trading distributor.
We operate as a controlled production system designed for long-term bulk supply contracts and OEM integration.
As a professional dihydroberberine powder manufacturer and bulk supplier, we provide stable-quality raw material suitable for nutraceutical brands, supplement formulators, and OEM/ODM projects.

How Dihydroberberine Works
Dihydroberberine is a metabolically reduced form of berberine. After oral intake, it is converted back into active berberine in the intestinal environment.
This conversion process is considered to improve the compound's absorption efficiency and systemic availability, compared to standard berberine, which is known for its limited bioavailability.
Key mechanism:
- DHB is absorbed more efficiently in the gastrointestinal tract
- Converted into berberine in vivo
- Supports improved utilization in metabolic pathways
- This makes it a preferred raw material in advanced nutraceutical formulations targeting glucose metabolism and energy balance support.
Why Choose Us as Your Dihydroberberine Supplier
Many suppliers perform well at sample stage, but struggle during large-scale production.The problem is usually not the ingredient itself, but inconsistent manufacturing control, unstable batch performance, and unreliable long-term supply capability.As production volume increases, these issues can lead to reformulation delays, QA instability, and supply-chain disruption.
✔ Stable Manufacturing Capacity
We support both small batch R&D orders and large-scale bulk supply for global brands.
✔ Strict Quality Control System
Each batch is tested using HPLC to ensure purity and consistency. COA is provided for every shipment.
✔ OEM / ODM Service Available
We support private label, formulation customization, and packaging solutions for supplement brands.
✔ International Compliance
Production follows GMP-standard management system with optional certifications depending on market requirements.
✔ Consistent Batch-to-Batch Quality
We focus on long-term supply reliability for commerical partners, ensuring stable raw material performance.
Manufacturing Process
Our dihydroberberine powder is produced under a controlled and standardized process to ensure stable quality and consistency.
- Raw material selection: High-quality berberine raw material is selected and pre-tested.
- Conversion process: Controlled reaction is used to convert berberine into dihydroberberine.
- Purification: Impurities and by-products are removed to ensure product safety.
- Drying & milling: The material is dried at low temperature and processed into fine powder.
- Quality testing: Each batch is tested by HPLC before release.
- Packaging: Final product is packed under controlled conditions for stable storage.

COA
| Test Item | Specification | Result | Test Method / Reference |
|---|---|---|---|
| Appearance | Pale yellow, fine powder | Complies | Visual inspection |
| Odor | Mild, earthy | Complies | Organoleptic evaluation |
| Taste | Slightly bitter | Complies | Organoleptic evaluation |
| Assay (Dihydroberberine) | ≥ 98.0% | 98.6% | HPLC, USP 36-NF31, Chapter 621 |
| Particle Size | 95% pass through 80 mesh | Complies | USP 36-NF31, Chapter 786 |
| Loss on Drying | ≤ 5.0% | 3.2% | USP 36-NF31, Chapter 731 |
| Residue on Ignition | ≤ 0.5% | 0.15% | USP 36-NF31, Chapter 281 |
| Heavy Metals | ≤ 10 ppm | 0.82 ppm | ICP-MS, USP 36-NF31, Chapter 233 |
| Lead (Pb) | ≤ 2.0 ppm | 0.18 ppm | ICP-MS, USP 36-NF31, Chapter 233 |
| Arsenic (As) | ≤ 2.0 ppm | 0.09 ppm | ICP-MS, USP 36-NF31, Chapter 233 |
| Cadmium (Cd) | ≤ 1.0 ppm | 0.05 ppm | ICP-MS, USP 36-NF31, Chapter 233 |
| Mercury (Hg) | ≤ 0.1 ppm | 0.01 ppm | ICP-MS, USP 36-NF31, Chapter 233 |
| Solvent Residue | ≤ 5000 ppm (Ethanol) | 45 ppm | GC, USP 36-NF31, Chapter 467 |
| Microbial Count | ≤ 1000 CFU/g | 30 CFU/g | USP 36-NF31, Chapter 61 |
| Yeast & Mold | ≤ 100 CFU/g | 10 CFU/g | USP 36-NF31, Chapter 61 |
| E. coli | Negative | Negative | USP 36-NF31, Chapter 62 |
| Staphylococcus aureus | Negative | Negative | USP 36-NF31, Chapter 62 |
Quality Assurance & Documentation
We provide full technical and quality documentation, including:
- Certificate of Analysis (COA)
- MSDS (Material Safety Data Sheet)
- Product Specification Sheet
- Third-party testing reports (upon request)
OEM / ODM & Private Label Service
We support global supplement brands with flexible manufacturing solutions:
- Custom formulation support
- Private label packaging
- Bulk ingredient blending
- Custom specifications (purity, particle size, etc.)
- Our goal is to help partners accelerate product development and market entry.
Applications
- Metabolic health supplement formulations
- Blood glucose support nutraceutical systems
- Weight management product development
- OEM / Private label supplement brands
- Functional nutrition capsules and tablets
FAQ
Q1: What is your MOQ for Dihydroberberine powder?
MOQ depends on packaging and customization requirements. Standard bulk orders are available for commerical clients.
Q2: Can you provide COA and third-party testing?
Yes, every batch comes with COA. Third-party testing can be arranged upon request.
Q3: Do you support OEM or private label production?
Yes, we provide full OEM/ODM services including formulation and packaging support.
Q4: What is the shelf life of the product?
The standard shelf life is 24 months under proper storage conditions.
Q5: How do you ensure product consistency?
We implement strict HPLC testing and batch traceability to ensure stable quality across all shipments.
Start Your Dihydroberberine Supply Partnership
We are ready to support your business with stable supply, consistent quality, and flexible OEM/ODM solutions.Whether you are developing a new supplement product or looking for a long-term raw material supplier, our team can provide full support from samples to bulk production.Contact us today to request COA, samples, or wholesale pricing: sales@botanicalcube.com.
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