Cotinus Coggygria Extract Fisetin Powder – High-Purity Flavonoid for Healthy Aging

Cotinus Coggygria Extract Fisetin Powder, also known as Fisetin Powder, Smoketree Extract, or Fisetin from Cotinus coggygria, is a plant-derived flavonoid ingredient widely used in healthy aging, cellular support, and antioxidant-focused formulations. Extracted from the wood of Cotinus coggygria (European smoketree), this ingredient is valued for its naturally high fisetin content and clean botanical origin, making it a preferred choice for dietary supplements, functional foods, and cosmetic applications.

Key Active Component – Fisetin

Fisetin is a naturally occurring flavonol found in limited botanical sources, and Cotinus coggygria is recognized as one of the most efficient commercial sources of high-purity fisetin. It is studied for its role in:

1. Supporting cellular longevity and healthy aging pathways
2. Providing strong antioxidant activity against oxidative stress
3. Assisting in inflammation modulation and metabolic balance

Compared with fisetin sourced from fruits or other plants, Cotinus coggygria–derived fisetin allows for higher assay levels and more consistent quality, which is critical for standardized formulations and dosage-controlled products.

Current Market Landscape

The global demand for fisetin powder is growing rapidly, driven by interest in senolytics, mitochondrial health, and anti-aging ingredients. Most brands sourcing fisetin focus on purity, traceability, and formulation flexibility, especially for capsules, tablets, powders, and functional blends. However, the market still faces challenges such as variable fisetin content, unstable supply chains, and limited customization options from generic suppliers.

Our Approach & Product Advantages

From our perspective as a long-term botanical extract manufacturer, this product stands out because of its source specificity and process control. We focus exclusively on Cotinus coggygria as the raw material, enabling:

1. High-assay fisetin powder with reliable batch-to-batch consistency
2. Optimized extraction and purification designed specifically for fisetin, not multi-flavonoid blends
3. Better suitability for anti-aging and longevity-positioned products where fisetin is the core functional claim
4. Rather than offering a one-size-fits-all fisetin ingredient, we tailor specifications based on real formulation needs, including particle size, solubility expectations, and target applications.

OEM & Customization Support

In addition to supplying bulk Cotinus Coggygria Fisetin Powder, we integrate this ingredient into our OEM/ODM solutions, supporting customers with:

1. Custom assay levels of fisetin
2. Finished dosage forms (capsules, tablets, blends)
3. Label-ready documentation and application guidance for global markets

This combination of botanical sourcing expertise + fisetin-focused processing + OEM flexibility allows our partners to move faster from concept to finished product while maintaining a clear differentiation in the competitive fisetin market.

Why Our Cotinus Coggygria Extract Fisetin Powder?

1. High-Purity Fisetin (Up to 98%)
Our Cotinus Coggygria Extract Fisetin Powder is produced using advanced extraction and multi-step purification processes, achieving fisetin purity of up to 98%. High purity means fewer impurities, more accurate dosing, and better formulation consistency for nutraceutical and healthy aging products.

2. Natural Plant-Based Source
Derived from Cotinus coggygria (smoketree), a well-recognized botanical source of fisetin, our fisetin powder is 100% plant-derived, free from artificial additives, fillers, or unwanted substances, while retaining the natural flavonol structure.

3. Multiple Specifications for Flexible Formulation
We offer 50%, 85%, and 98% fisetin powder to meet different application needs, cost targets, and formulation requirements, making it easier for brands to scale products across different market segments.

4. Stable Quality & OEM Support
With controlled raw material sourcing and fisetin-specific processing, we ensure batch-to-batch stability. In addition to bulk supply, we support OEM/ODM solutions, including customized specifications, blends, and finished dosage forms.

Name	Fisetin	Molecular Weight	286.236
CAS No	528-48-3	Boiling Point	599.4±50.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3	Melting Point	330ºC
Molecular Formula	C₁₅H₁₀O₆	Flash Point	233.0±23.6 °C
Solubility	Fisetin is poorly soluble in water but slightly soluble in ethanol and DMSO.

*Fisetin is a yellowish-brown powder that is insoluble in water and has a bitter taste.

Chromatogram of Fisetin 98% HPLC:

Chromatogram of Fisetin Powder

COA

Testing Items	Testing Method	Testing Results	Units
Purity	High-Performance Liquid Chromatography (HPLC)	≥ 98%	%
Bulk Density	Customer-provided Method	0.45	g/mL
Moisture	Drying Oven Method	≤ 1.0	%
Ash Content	Furnace Ashing Method	≤ 0.5	%
Total Plate Count	Plate Count Method	< 10	CFU/g
Yeasts and Molds	Plate Count Method	< 10	CFU/g
Salmonella	Enrichment and Selective Culture Method	Not Detected	Absent/25g
Escherichia coli	Enrichment and Selective Culture Method	Not Detected	Absent/25g
Staphylococcus aureus	Enrichment and Selective Culture Method	Not Detected	Absent/25g
Heavy Metals	Atomic Absorption Spectroscopy
- Arsenic (As)	Atomic Absorption Spectroscopy	< 2	ppm
- Lead (Pb)	Atomic Absorption Spectroscopy	< 2	ppm
- Cadmium (Cd)	Atomic Absorption Spectroscopy	< 1	ppm
- Mercury (Hg)	Atomic Absorption Spectroscopy	< 0.1	ppm

The production process of Fisetin Powder

1. Extraction Methods:

a) The dried Cotinus coggygria Scop leaves are taken.

b) The leaves are washed to remove any dirt or impurities.

c) The leaves are then dried at a moderate temperature below 60°C to avoid any damage to the flavonoids.

d) The dried leaves are crushed into a powder.

e) The powdered leaves are then subjected to solvent extraction using a suitable solvent such as methanol, ethanol, or water.

f) The resulting extract is concentrated using a rotary evaporator.

g) The concentrated extract is dried to obtain the Cotinus coggygria extract.

2. Quality Control Measures:

a) To ensure the purity and identity of the plant material, the Cotinus coggygria Scop plant

b) species used should be authenticated using appropriate methods like macroscopic and microscopic evaluation.

c) The extracted fisetin extract should be tested for the presence of pesticide residues to ensure that it is free from any harmful contaminants.

d) The fisetin should be tested for the presence of heavy metals to ensure that it is safe for human consumption.

3. Standards Compliance:

The manufacturing process should comply with the current good manufacturing practices (cGMP) regulations laid down by regulatory authorities.

The product should meet pharmacopoeial standards such as the United States Pharmacopeia (USP) or the European Pharmacopoeia (Ph. Eur.) for quality and purity.

Applications & Recommend Dosage of Fisetin Powder

Application	Working Mechanism	Suitable Specification	Recommend Dosage
Anti-Inflammatory	Fisetin inhibits the production of inflammatory mediators such as cytokines and enzymes, reducing inflammation in the body.	≥ 95% purity	50-100 mg/day
Antioxidant	Fisetin acts as a potent antioxidant, scavenging free radicals and protecting cells from oxidative stress.	≥ 98% purity	50-200 mg/day
Neuroprotection	Smoke tree extract enhances brain-derived neurotrophic factor (BDNF) levels and protects against neurodegenerative diseases by reducing oxidative damage and inflammation.	≥ 95% purity	100-250 mg/day
Anti-Aging	Fisetin activates sirtuins, which are involved in regulating cellular aging processes and promoting longevity by activating antioxidant defense mechanisms.	≥ 95% purity	50-200 mg/day
Metabolic Health	Fisetin improves metabolic health by modulating insulin sensitivity, reducing glucose levels, and promoting mitochondrial function in cells.	≥ 98% purity	100-250 mg/day
Skin Health	Fisetin Powder has skin-protective effects by reducing UV-induced DNA damage, preventing collagen breakdown, and inhibiting inflammatory skin conditions.	≥ 95% purity	50-150 mg/day
Cardiovascular Health	Fisetin improves cardiovascular health by reducing oxidative stress, inflammation, and lipid levels, and promoting vascular function.	≥ 98% purity	100-250 mg/day

Popular Fisetin Powder Formulations on the Market

Formulation Combination	Common Co-Ingredients	Main Positioning	Why Fisetin Is Used
Fisetin + Quercetin	Fisetin, Quercetin	Senolytic & Healthy Aging	Both are flavonols; fisetin complements quercetin in cellular aging and antioxidant support
Fisetin + Resveratrol	Fisetin, Resveratrol (Polygonum Cuspidatum)	Longevity & Cellular Protection	Combines two well-known polyphenols linked to aging-related pathways
Fisetin + NMN / NR	Fisetin, NMN or NR	NAD⁺ Support & Anti-Aging	Fisetin is often added to NAD⁺ formulas to strengthen longevity positioning
Fisetin + Spermidine	Fisetin, Spermidine	Autophagy & Cellular Renewal	Popular in advanced anti-aging and cellular renewal supplements
Fisetin + Pterostilbene	Fisetin, Pterostilbene	Brain Health & Antioxidant Support	Improves formulation appeal in cognition and oxidative stress products
Fisetin + Curcumin	Fisetin, Curcumin (with Piperine)	Anti-Inflammatory Support	Targets inflammation and oxidative stress from multiple botanical pathways
Fisetin + EGCG	Fisetin, Green Tea Extract (EGCG)	Metabolic & Antioxidant Formula	Combines flavonols and catechins for broader antioxidant coverage
Fisetin + Vitamin D3 + K2	Fisetin, Vitamin D3, Vitamin K2	Healthy Aging & Bone Support	Common in senior-focused or longevity daily formulas
Fisetin + CoQ10 / PQQ	Fisetin, Coenzyme Q10 or PQQ	Mitochondrial Health	Used in energy and mitochondrial-support supplements
Fisetin + Astaxanthin	Fisetin, Astaxanthin	Skin Health & Anti-Oxidation	Combines lipid- and water-associated antioxidants for beauty-from-within products

Bulk Fisetin Supplier & OEM

Choosing a reliable manufacturer for your anti-aging product line makes all the difference in market success. We specialize in high-purity Cotinus Coggygria extract, providing stable bulk supply and flexible OEM services tailored to your brand's specifications. Our facility holds multiple international certifications to ensure every batch meets rigorous safety and quality standards. If you want to elevate your longevity supplements with a potent, science-backed ingredient, we are ready to help you scale. Reach out to discuss wholesale pricing or custom formulations at sales@botanicalcube.com.

Cotinus Coggygria Extract Fisetin Powder

Hot Tags: Cotinus Coggygria Extract Fisetin Powder, China, suppliers, manufacturers, factory, wholesale, price, bulk, discount, Natural Dietary Supplements Extracts, , Saw Palmetto Extract Powder, Ginseng Extract Powder, Polygonum Cuspidatum Extract Powder, Spinach Extract Ecdysterone