Botanical Cube Inc. is one of the most professional manufacturers and suppliers of Sodium Hyaluronic Acid Powder in China, featured by quality products and good price. Please rest assured to wholesale bulk discount Sodium Hyaluronic Acid Powder from our factory.
Our Hyaluronic Acid (HA) / Sodium Hyaluronate Powder is engineered for formulators who need consistent molecular weight control, high purity stability, and predictable performance across skincare, injectable, and supplement systems. Unlike standard market materials that vary between batches, we focus on tight specification control from fermentation to final drying, ensuring every lot behaves the same in real formulation conditions.
HA powder, we support formulation-driven sourcing:
- Multiple molecular weights aligned with different product functions
- Batch-to-batch consistency for scale-up manufacturing
- Flexible MOQ for R&D and pilot production
- OEM support for branded product lines
- Stable long-term supply planning for continuous production cycles
Our powder form is optimized for:
- Multiple molecular weight options available (Low / Medium / High MW) for different skin penetration and viscosity needs
- Ultra-low impurity profile designed for sensitive skin and high-end dermal applications
- Stable hydration performance with excellent water-binding consistency in finished formulations
- Controlled bio-fermentation process reducing batch variability common in lower-cost supply chains
- Designed for scalable manufacturing use, from lab testing to full-scale production
Hyaluronic Acid (HA), also known as Sodium Hyaluronate when neutralized form is used, is a naturally occurring polysaccharide widely applied in skincare, ophthalmic solutions, joint health supplements, and medical aesthetics. It is valued for its exceptional ability to retain moisture-up to 1000 times its own weight in water.
Manufacturing Process
We use a controlled microbial fermentation system followed by multi-stage purification to ensure high consistency and safety.
Process Flow:
- Strain selection & fermentation (non-animal origin)
- Controlled pH & temperature cultivation
- Filtration & cell removal
- Protein elimination & impurity reduction
- Activated carbon purification
- Ultrafiltration concentration
- Alcohol precipitation
- Vacuum drying & milling
- Final sieving & batch standardization
- Process Flow Diagram
Quality Control System
Each batch is tested under a multi-layer QC system:
- Raw material microbial screening
- Fermentation monitoring (real-time parameters)
- Intermediate purity validation
- Final molecular weight verification
- Stability testing under accelerated conditions
This ensures consistent performance in both cosmetic emulsions and pharmaceutical-grade systems.
COA
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white fine powder | Conforms |
| Identification | Positive reaction (IR / UV) | Conforms |
| Assay (Hyaluronic Acid) | ≥ 95.0% | 97.8% |
| Sodium Hyaluronate Content | ≥ 95.0% (dry basis) | 96.5% |
| Molecular Weight | 0.8 – 1.5 MDa (standard grade) | 1.22 MDa |
| Intrinsic Viscosity | 1.0 – 2.0 m³/kg | 1.45 m³/kg |
| Glucuronic Acid | ≥ 44.0% | 46.2% |
| Protein Content | ≤ 0.1% | 0.04% |
| Nucleic Acids | ≤ 0.5% | 0.18% |
| Heavy Metals (Total) | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 2 ppm | 0.6 ppm |
| Arsenic (As) | ≤ 1 ppm | < 0.3 ppm |
| Mercury (Hg) | ≤ 0.1 ppm | < 0.05 ppm |
| Cadmium (Cd) | ≤ 1 ppm | < 0.2 ppm |
| Loss on Drying | ≤ 10.0% | 6.1% |
| Residue on Ignition | ≤ 20.0% | 12.3% |
| pH (0.1% solution) | 5.0 – 8.5 | 6.8 |
| Particle Size | 80–120 mesh | 100 mesh |
| Viscosity (0.5% solution, 25°C) | 300 – 800 mPa·s | 620 mPa·s |
| Total Plate Count | ≤ 100 CFU/g | < 10 CFU/g |
| Yeast & Mold | ≤ 10 CFU/g | < 10 CFU/g |
| E. coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Staphylococcus aureus | Negative | Negative |
| Storage | Cool, dry, sealed condition | Conforms |
| Shelf Life | 24 months | Conforms |
FAQs
1. What is the difference between Hyaluronic Acid and Sodium Hyaluronate?
Hyaluronic Acid (HA) is the original molecule, while Sodium Hyaluronate is its more stable salt form. In practice, Sodium Hyaluronate is more commonly used in formulations because it has better water solubility, improved stability, and easier processing in cosmetic and supplement systems.
2. What molecular weight should I choose?
- Low Molecular Weight (LMW): Better skin penetration, often used in anti-aging serums
- Medium Molecular Weight: Balanced hydration and skin surface effect
- High Molecular Weight (HMW): Strong film-forming and surface hydration, ideal for creams and masks
- Most formulators combine different molecular weights for multi-layer hydration effects.
3. Is your Hyaluronic Acid animal-derived?
No. Our Hyaluronic Acid is produced through controlled microbial fermentation, ensuring it is non-animal derived, vegan-friendly, and suitable for global cosmetic standards.
4. Can Sodium Hyaluronate be used in oral supplements?
Yes, food-grade or nutraceutical-grade Sodium Hyaluronate can be used in capsules, powders, and functional beverages. It is commonly used in beauty-from-within formulations targeting skin hydration and elasticity support.
5. Is it stable in cosmetic formulations?
Yes. Sodium Hyaluronate is stable across a wide pH range (typically 5.0–8.5) and is compatible with most cosmetic ingredients such as peptides, vitamins, niacinamide, and botanical extracts.
6. Why does molecular weight matter so much?
Because it directly affects how Hyaluronic Acid behaves:
- Texture (gel strength & viscosity)
- Skin surface vs deeper hydration performance
- Absorption speed and formulation stability
- Choosing the right molecular weight is critical for product performance.
8. Can it be mixed with active ingredients like Vitamin C or retinol?
Yes, Sodium Hyaluronate is highly compatible. It is often used to buffer irritation and improve skin tolerance when combined with stronger actives like retinol or acidic Vitamin C derivatives.
Sodium Hyaluronate Powder Supplier & OEM Partner
In a competitive Hyaluronic Acid market, real value comes from consistent quality, stable molecular weight control, and reliable performance in every batch. Our Sodium Hyaluronate Powder is designed to support smooth scale-up from formulation development to full production.
With flexible specifications and fermentation-based production, we help reduce formulation risk and improve efficiency in skincare, nutraceutical, and specialty applications.For bulk supply, OEM projects, or customized requirements, we are ready to support your next development stage.
Contact: sales@botanicalcube.com.
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