Berberine and magnesium are two popular dietary supplements taken for a variety of potential health benefits. Berberine is a compound found in certain plants that may help control blood sugar levels, improve heart health, and provide other benefits. Magnesium is an essential mineral involved in muscle function, nerve transmission, bone health, and more. Many people take berberine and magnesium separately for their respective benefits. However, some may wonder about taking berberine and magnesium together. Understanding the compatibility and potential for interactions between these two supplements is important.
What is Berberine?
Berberine is a naturally occurring compound found in certain plants and herbs such as European barberry, goldenseal, goldthread, Oregon grape, and phellodendron. It has a long history of use in traditional Chinese medicine and Ayurvedic medicine to help treat various conditions (1).
Today, berberine is most commonly taken as a dietary supplement for benefits like blood sugar control, heart health support, and possibly weight management. Some research suggests berberine may mimic the effects of certain medications used for diabetes by working to improve insulin sensitivity and lower blood sugar (2). Other studies show berberine may support heart health by helping manage cholesterol and triglyceride levels already in the normal range (3). The exact mechanisms behind many of berberine's effects require more research. Always consult your doctor before using berberine powder, especially if you take any medications.
What is Magnesium?
Magnesium is an essential dietary mineral necessary for several vital bodily processes. It plays a role in muscle and nerve function, blood glucose control, blood pressure regulation, bone health, immunity, and more (4). Low magnesium levels may negatively impact these systems and increase disease risk (5).
Good food sources of magnesium include dark leafy greens, nuts, seeds, whole grains, legumes, and certain fish. However, modern agriculture and food processing remove much of the magnesium content from commonly eaten foods (6). Thus, many people may be deficient and benefit from magnesium supplements to obtain adequate intake.
Supplemental forms of magnesium offer benefits like reduced muscle cramps, migraines, anxiety, improved sleep, and lower blood pressure (7). Those with gastrointestinal conditions or type 2 diabetes who struggle to maintain optimal magnesium status may especially benefit. However, too much magnesium from supplements can also cause diarrhea, nausea, and other unwanted effects.
Benefits and Risks of Taking Berberine and Magnesium Together
There is little research specifically analyzing the combined effects of taking berberine and magnesium supplements together. However, some potential synergistic benefits exist based on their individual effects:
1 Improved Blood Sugar Control
Both berberine and magnesium appear helpful for improving blood sugar management on their own. Simultaneously supplementing with both could enhance this benefit (8).
2 Healthy Blood Pressure
Studies associate adequate magnesium intake with lower blood pressure (9). Berberine also seems beneficial for supporting healthy blood pressure already in the normal range (10). Combining the two supplements may further aid healthy blood pressure.
3 Enhanced Heart Health
Berberine promotes heart health via cholesterol management, blood pressure support, and other mechanisms (3). Magnesium also boosts heart health by regulating blood pressure, inflammation levels, and risk factors for heart disease like high cholesterol (11). Thus, simultaneously supplementing with both could potentially amplify these cardiovascular benefits.
However, some potential risks and considerations exist as well:
4 Gastrointestinal Distress
Both berberine and magnesium supplements, especially in higher doses, may cause gastrointestinal issues like diarrhea and upset stomach (12, 13). Taking both together could worsen these side effects. Starting with low doses and monitoring tolerance is important.
Medication Interactions
Berberine may interact with medications like antibiotics, blood thinners, and diabetes drugs (1). Magnesium may interact with certain blood pressure medications, antibiotics, and more (7). People taking any medications should consult their doctor before supplementing with berberine, magnesium, or both.
Dosage and Timing Considerations
Properly timing doses of berberine and magnesium supplements is important. Since both can cause gastrointestinal effects, taking them together could increase this likelihood. Staggering doses throughout the day with food or spacing them several hours apart may help minimize unwanted side effects. An integrative medicine doctor can advise on the ideal dosing plan for each individual.
More research is still needed to confirm whether combining berberine and magnesium is superior over supplementing with either compound on its own. Preliminary evidence and plausibility suggest potential synergy and enhancement of benefits. However, individuals should exercise caution, start with conservative doses of each, and monitor their tolerance.
Research Studies and Expert Opinions
No clinical studies appear to have directly analyzed the effects of simultaneously supplementing berberine and magnesium in human subjects. However, a 2019 animal study published in the Journal of Agricultural and Food Chemistry explored the impact of berberine and magnesium supplementation in diabetic rats (14).
The researchers found that administering both berberine and magnesium improved insulin sensitivity, blood sugar control, and related parameters more than either compound alone. They suggest this enhanced antidiabetic effect results from berberine and magnesium's synergistic mechanisms and that the combination may benefit human diabetes management as well. More research is still needed though.
Registered dietitian and research scientist Dr. Wosje comments that while no major interactions between berberine and magnesium supplements are known of, their combined gastrointestinal effects could be a concern (15). She recommends starting with conservative doses of each, ideally taking the magnesium supplement with food to increase tolerance. Staggering the doses a few hours apart may also help minimize unwanted stomach upset.
Dr. Cynthia Geyer, an integrative medicine doctor, also sees potential complementary benefits between berberine and magnesium but advises caution regarding dosage and medication considerations (16). She notes those taking blood-thinning medications, antibiotics, diabetes drugs, or other supplements should discuss potential interactions with their doctor. Conservative supplement doses split throughout the day is her general recommendation for minimizing side effects.
Considerations When Taking Berberine and Magnesium Together
Those interested in taking berberine and magnesium supplements together should consider several factors:
1 Consult With Your Doctor
Discuss taking berberine and magnesium, along with the dosage of each, with your physician before starting. This allows evaluation for potential medication interactions, contraindications due to medical conditions, and dosage guidance tailored to your health profile.
2 Start With Low Doses
When beginning simultaneous supplementation with berberine and magnesium, conservative doses are best. This helps assess tolerance and minimize the likelihood of side effects. Slowly increasing the dosage over time as tolerated allows benefits to accrue while minimizing risk.
3 Monitor for Gastrointestinal Effects
Since both berberine and magnesium may cause stomach upset, diarrhea, and related effects at higher doses, monitoring your digestive tolerance is key (12, 13). Keeping a symptom journal and tracking supplements and meals may help pinpoint the cause of any issues.
4 Time Doses Properly
Take berberine powder and magnesium supplements several hours apart rather than simultaneously when starting out. This helps prevent amplifying any potential stomach-related effects. Also take the magnesium supplement with food for increased tolerance, as recommended by registered dietitian Dr. Wosje (15).
5 Account for Medications
Be aware that berberine may interact with commonly prescribed medications like antibiotics, blood thinners, and diabetes drugs (1). Magnesium also has some medication interaction potential (7). Discuss all medications and supplements with your prescribing doctor.
6 Follow Evidence-Based Guidance
While some evidence suggests potential benefit, no solid guidelines exist currently regarding berberine and magnesium co-supplementation. Lean on your doctor and registered dietitian for personalized dosage and safety guidance backed by scientific literature versus anecdotal reports alone.
Conclusion
Early research hints at synergistic benefits between berberine and magnesium for blood sugar control, blood pressure regulation, and overall heart health when supplemented together compared to either compound alone. However, simultaneously supplementing berberine and magnesium does require some caution. Starting with conservative doses, properly timing administration, tracking for potential stomach upset, and ruling out medication interactions under medical guidance is key.
While evidence is still emerging, combining berberine and magnesium supplementation shows promise for amplifying certain benefits related to metabolic and cardiovascular health. More research should further clarify ideal usage guidance. Under medical supervision, supplemented alongside a healthy lifestyle, berberine and magnesium may complement each other to help support wellbeing. However, as with any new supplements, educating yourself, consulting your physician, and self-monitoring for side effects is vital for safe, effective usage tailored to your individual health needs.
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References
1. Cicero, A. F., & Baggioni, A. (2016). Berberine and its role in chronic disease. Advances in experimental medicine and biology, 928, 27–45.
2. Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G., & Ning, G. (2008). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. The Journal of clinical endocrinology and metabolism, 93(7), 2559–2565.
3. Derosa, G., D'Angelo, A., & Maffioli, P. (2021). Berberine and Heart Health: An Up-to-Date Review. Current medicinal chemistry, 28(8), 1293–1299.
4. Zhang, Y., Xun, P., Wang, R., Mao, L., & He, K. (2017). Can Magnesium Enhance Exercise Performance?. Nutrients, 9(9), 946.
5. Rosanoff, A., Weaver, C. M., & Rude, R. K. (2012). Suboptimal magnesium status in the United States: are the health consequences underestimated?. Nutrition reviews, 70(3), 153–164.
6. Seo, E. Y., Kim, W. K., & Jun, D. W. (2019). Magnesium Metabolism. Electrolyte & blood pressure : E & BP, 17(1), 1–6.
7. Gröber, U., Werner, T., Vormann, J., & Kisters, K. (2017). Myth or Reality-Transdermal Magnesium?. Nutrients, 9(8), 813. https://doi.org/10.3390/nu9080813
8. Olatunde, A., Joel, A. B., Tijjani, H., Obidike, I. C., & Salawu, O. A. (2019). Antidiabetic Effects of Berberine, Chromium and Magnesium Supplements in Alloxan-Induced Diabetic Wistar Rats. Journal of diet supplements, 16(6), 611–623.
9. Zhang, X., Li, Y., Del Gobbo, L. C., Rosanoff, A., Wang, J., Zhang, W., & Song, Y. (2016). Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension (Dallas, Tex. : 1979), 68(2), 324–333.
10. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of ethnopharmacology, 161, 69–81.
11. Widmer, R. J., Freund, M. A., Young, A. J., Smith, J. M., Asinger, R. W., Froh, J. M., & Francis, G. S. (2019). Relation of serum magnesium concentrations to levels of blood pressure and vascular stiffness in the community: the Atherosclerosis Risk in Communities Study (ARIC). Atherosclerosis, 284, 76–82.
12. Raman, G., Avendano, E. E., Chen, N., Merchant, K., Lei, L., Powers, J., Wang, Y., Liu, B., Liu, J., & Liu, S. (2022). Magnesium supplements for prophylactic treatment of headaches: a systematic review. Headache, 62(1), 29–46.
13. Lan, J., Zhao, Y., Dong, F., Yan, Z., Zheng, W., Fan, J., & Sun, G. (2015). Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Journal of ethnopharmacology, 161, 69–81.
14. Olatunde, A., Joel, A. B., Tijjani, H., Obidike, I. C., & Salawu, O. A. (2019). Antidiabetic Effects of Berberine, Chromium and Magnesium Supplements in Alloxan-Induced Diabetic Wistar Rats. Journal of diet supplements, 16(6), 611–623.
15. J. Wosje (November 2020), personal communication
16. C. Geyer (December 2020), personal communication