Why does curcumin require improved bioavailability?
Curcumin is a natural diketone compound extracted from the rhizome of turmeric. It has a low polarity specificity and is insoluble in water and various vegetable oils. Studies have shown that the oral bioavailability of curcumin is only 1%, and most of it is excreted in the feces as a prototype. Therefore, curcumin requires the help of bioavailability enhancers in order to be absorbed into the body and unlock its full health potential. The term bioavailability enhancer was first documented to have been coined by Indian scientists.
Why is piperine used as a bioavailability enhancer?
Piperine is a natural compound extracted from the mature seeds of black pepper, and in addition, it is a bioavailability enhancer that improves the absorption and bioavailability of drugs. Piperine was discovered and scientifically validated by Indian scientists in 1976 as the world's first bioenhancer. Bioavailability is an indicator of the degree and rate of absorption of the active ingredient of a drug into the body. It makes micronutrients more easily absorbed by the body, mainly by increasing membrane fluidity in the intestine. In addition, it contains enzyme-inhibiting molecular structures that promote absorption by inhibiting metabolic enzymes and thereby reducing drug metabolism.
How does piperine improve the bioavailability of curcumin?
Curcumin makes up only about 5% of turmeric, and piperine, the active ingredient similar to black pepper, also makes up about 5% of black pepper. Studies have found that ingesting just 20 mg of piperine per 2 g of turmeric can increase the absorption of curcumin, the potent active ingredient in turmeric, by 2000%. Specifically how piperine enhances the bioavailability of curcumin are the following points.
1. Piperine is an inhibitor of glucuronic acid, curcumin is metabolized by glucuronic acid in the body so that the active ingredient is retained, not easily discharged in reduced quantities, stays longer in body tissues, and promotes intestinal absorption.
2. Piperine has been experimentally shown to increase the serum concentration of curcumin, thus allowing curcumin to be released and absorbed within the expected time.
3. Piperine acts by non-specific inhibition of the mixed function oxidase system, which slows down the metabolic biodegradation of curcumin and improves the bioavailability of the drug.
What you need to know about curcumin and piperine compounding
1. The common form of curcumin and piperine combination on the market is in the form of capsules, the specific need to use a few weeks and months to see the results, it does not achieve immediate and rapid repair, the exact time will depend on each person's constitution, as well as the intake and use, the specific need to consult a professional.
2. The side effects of curcumin and piperine will be minimal when taken in moderation, although curcumin has a good safety record when taken in higher doses, there can be minor adverse side effects. The side effects of piperine in black pepper are rare, but studies in rats have shown that it slows blood clotting and should be avoided by people with blood disorders or those about to undergo surgery.JECFA and EFSA recommend that an allowable daily intake of 3 mg/kg of curcumin is safe for humans.
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| Black Pepper Extract (Piperine) | Turmeric Extract (Curcumin) |
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