Dihydromyricetin (DHM) is a characteristic flavonoid compound that has recently gained popularity as an enhancement and food-added substance. It is obtained from Hovenia dulcis, a tree local to China and Japan that has a long history of purpose in customary homegrown medication. DHM shows guarantee as a disease prevention agent and well-being advancing fixing.
Understanding Dihydromyricetin
Chemically speaking, dihydromyricetin is classified as a flavanonol, which is a type of flavonoid antioxidant. It can be extracted from the leaves, fruit, and branches of the Hovenia dulcis tree. DHM is also found in lower concentrations in tea, berries, and other plant sources. The compound is available commercially in powder, capsule, or liquid extract form for use as a supplement.
Is Dihydromyricetin an Antioxidant?
Yes, research has confirmed the potent antioxidant activity of DHM. In lab tests, it shows more grounded free revolutionary abilities to rummage contrasted with other famous cell reinforcements like L-ascorbic acid, vitamin E, and resveratrol. The cell reinforcement impacts of DHM are accepted to be fundamentally answerable for the vast majority of its noticed medical advantages. By killing free revolutionaries, DHM might assist with safeguarding cells against oxidative harm connected with maturing, cardiovascular illness, and neurodegeneration.
Dihydromyricetin in Dietary Supplements
One of the most common uses of dihydromyricetin powder is as an ingredient in dietary supplement products. DHM supplements are marketed for benefits such as:
Liver support - Animal studies indicate DHM can protect liver cells, improve detoxification, and accelerate alcohol metabolism. More research is needed, but DHM shows promise for promoting already healthy liver function.
Cognitive function - DHM may act as a neuroprotectant by reducing oxidation and inflammation in the brain. Studies suggest it could help maintain clarity of thinking, focus, and short-term memory.
Hangover relief - One small human trial found taking DHM before drinking reduced hangover severity. It’s believed to work by speeding up the breakdown of acetaldehyde, a toxic byproduct of alcohol.
Circulation - Early studies show DHM can potentially improve circulation by promoting healthy blood vessels and blood flow. This effect may also benefit heart health.
Dihydromyricetin in the Food Industry
In recent years, DHM has gained attention for its use as an ingredient and additive in foods and beverages:
Flavor enhancer - DHM can mask bitter flavors and improve overall flavor profiles. This allows for reduced sugar without compromising taste.
Preservative - Research shows DHM has antimicrobial properties that can extend shelf life and slow spoilage caused by bacteria, yeasts, and molds.
Bitter blocker - DHM binds to bitter taste receptors on the tongue. This mechanism decreases perceived bitterness in foods and drinks.
Nutritional booster - Fortifying drinks like juices and teas with DHM can provide an extra functional benefit related to its antioxidant activity.
More research is underway to evaluate the efficacy and safety of DHM as an additive. Initial studies are very promising.
Is dihydromyricetin good for you?
Early research suggests dihydromyricetin (DHM) powder may offer several health benefits:
Liver protection: Animal studies indicate that DHM protects liver cells from alcohol toxicity. A mouse study found that DHM could prevent alcohol-induced fatty liver disease. It's believed to work by enhancing alcohol metabolism and clearance of acetaldehyde, a toxic byproduct.
Neuroprotective effects: DHM improved memory and cognitive function in a rat model of Alzheimer's disease. It also reduced neuronal damage and amyloid-beta protein deposits in the brain. Researchers attributed these benefits to DHM's antioxidant and anti-inflammatory properties.
1. Hangover relief: A randomized controlled trial in young adults found that taking a DHM supplement before drinking significantly reduced hangover severity. DHM decreased nausea, headache, fatigue, and other symptoms by up to 33%.
2. Heart health: DHM improved blood flow and vascular function in animal studies. It also reduced ischemic injury and myocardial infarct size in rats. The benefits are linked to increased nitric oxide production and antioxidant effects.
3. Antiviral activity: Test tube research indicates DHM has antiviral effects against influenza, hepatitis C virus, and other viruses. It was shown to reduce viral replication and entry into host cells.
What does Dihydromyricetin do in the body?
Dihydromyricetin powder has multiple proposed mechanisms of action:
- Powerful antioxidant that scavenges free radicals and boosts glutathione levels
- Increases alcohol metabolism by enhancing the activity of liver enzymes like alcohol dehydrogenase
- Binds to GABA receptors which may improve neurological signaling
- Stimulates nitric oxide production which improves circulation and vasodilation
- Protects mitochondria and inhibits apoptosis (programmed cell death)
- Lowers inflammation by reducing pro-inflammatory cytokines and NF-kB activation
- May act as a neuroprotectant by blocking beta-amyloid formation in the brain
- Provides antibacterial effects against some foodborne pathogens like E. coli
What are the side effects of DHM?
Currently, there are no well-documented side effects of dihydromyricetin powder in humans. Potential side effects could include:
- DHM may interact with alcohol leading to exacerbated intoxication
- High doses may irritate the gastrointestinal tract
- Could potentially affect blood clotting and interact with anticoagulant medication
- Limited data on long-term safety with prolonged use
- May cause drowsiness and fatigue, especially when combined with alcohol
- Headache, nausea, and dizziness are possible at very high doses
DHM side effects do not appear to be common but more research is still needed on its long-term safety. Those with liver conditions should exercise caution with DHM supplements before consulting a doctor.
When should you take dihydromyricetin?
To reduce intoxication and hangover symptoms, take DHM 30-60 minutes before drinking alcohol. The optimal dosage for hangover prevention appears to be around 200-400mg. For general health, DHM supplements can be taken daily with food. It's best to start with lower doses and increase slowly as needed. Cycling on and off DHM every few months is recommended rather than taking it continuously.
Conclusion
Early examination shows guarantees that the regular compound dihydromyricetin may offer different medical advantages connected with its disease prevention agent, calming, and antiviral movement. Be that as it may, human clinical preliminaries are as yet restricted and bigger investigations are required, particularly to assess long-haul wellbeing with supplementation. Similarly as with any new enhancement, counseling your PCP before use is significant.
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References
1. Chen, D., Cao, L., Wang, B., Wang, D., Yang, F., & Zeng, X. (2017). Dihydromyricetin improves cognitive deficits through the nitric oxide/cyclic guanosine monophosphate pathway in rats with vascular dementia. Journal of Molecular Neuroscience, 61(3), 421-430.
2. Jiang, W., Hu, M., & Wang, X. (2016). Dihydromyricetin inhibits the bitterness of antibacterial peptide infusion in liquid food. Journal of Food Quality, 39(5), 523-529.
3. Li, S., Chen, H., Li, X., Pei, J., McClements, D. J., & Decker, E. A. (2017). Chemical stabilization of dihydromyricetin from vine tea (Ampelopsis grossedentata) using natural antioxidants and its effects on antioxidant activity. Journal of Agricultural and Food Chemistry, 65(30), 6331-6338.
4. Shen, Y., Lindemeyer, A. K., Spigelman, I., Shao, X. M., Olsen, R. W., & Liang, J. (2017). Dihydromyricetin ameliorates behavioral deficits and reverses the neuropathology of transgenic mouse models of Alzheimer's disease. Journal of Alzheimer's Disease, 60(1), 225-242.
5. Zheng, X., Li, Y., Shi, H., Sun, H., Jiang, M., Pu, S., & Lu, J. (2016). Effects of dihydromyricetin on acetaldehyde metabolism and acute ethanol-induced liver injury using a mouse model of binge drinking. Chemico-biological Interactions, 254, 165-171.