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Anti-inflammatory And Anti-allergic Mechanism Of Magnolia Officinalis Extract
- Mar 22, 2022 -

Brief introduction of Magnolia bark extract

1. Magnolia is produced in southern Shaanxi, southeastern Gansu, southeastern Henan western Hubei, southwestern Hunan, northeastern Guizhou, and Sichuan. We will use magnolia bark for extraction It takes more than ten years to harvest the bark, and the content of total phenols is 10%-20%, most of which are more than 15%. Here total phenols = honokiol + magnolol The ratio of most of the two monophenols is close to one to one.

2. An important reference index for cosmetic ingredients, anti-allergy should be considered. As a natural ingredient, Magnolia has an advantage in this regard. The barrier function of the skin is very important. In addition to choosing mild ingredients not to stimulate, we should also pay attention to avoid excessive cleaning do a good job of sun protection, etc., to reduce the damage to the skin barrier.

Magnolia treeDry magnolia barkMagnolia powder
Magnolia treeDry magnolia barkMagnolia powder

Why choose Magnolia bark extract for Anti-inflammatory and anti-allergic

1. The advantage of Magnolia bark extract is reflected in the omnipotent type of antibacterial effect, which has an inhibitory effect on almost common flora, but it has limitations, such as solubility, irritation, and price. Solubility, insoluble in water, only suitable for creams, eye creams, eye creams are too irritating to be used in the market, which affects the use of products, and even those with sensitive skin will react.

2. The reason is that the efficacy of the two monophenols is almost the same and has a coordinated effect. Compared with honokiol, honokiol is better than magnolol, and its irritation is low. But the price is higher.

3. To improve skin irritation, it is necessary to inhibit histamine. Similarly, allergic reactions require anti-lymphokines (and interleukins). The anti-inflammatory effect of Magnolia Officinalis extract is to inhibit one of them.

Sensitive skinSkin irritationSkin allergies
NatureSkin conditionSkin reactionSkin reaction
CauseImpaired barrier function and abnormal neurological function.Sensitive skin, physical and chemical irritation (acidic substances, organic solvents, surfactants)Poor barrier function/susceptibility, allergens (lipid-soluble, low molecular weight substances)
CellCells, keratinocytes, keratinocytesMast cells, basophils, nonspecific T lymphocytesPhagocytes, specific T lymphocytes
SubstanceCell and stratum corneum structure-related componentsHistamine, KininogenaseLymphokines, Interleukins
PerformanceDamaged epidermal structure, dryness, tightness, rednessErythema, edema, desquamation, keratinocyte vesicular changesSimilar to irritant response, systemic lesions
FeaturesPoor irritant tolerance, prone to allergic reactionsDirect reaction after contact, local reaction after contact, any substance is possibleLatency, complex systemic response, symmetry of onset sites
RelationSensitive skin is prone to skin irritation and allergy, which can be regarded as one of the reasons for both: skin irritation and allergy are both reactions of sensitive skin to exogenous stimuli.

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